Human skeletal muscle fibre type grouping and collateral re-innervation.

Human skeletal muscle fibre type grouping and collateral re-innervation.

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism

Skeletal muscle is composed of both slow-twitch oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function and eventually whole-body physiology. Here we show that the mesodermal transcription factor T-box 15 (Tbx15) is highly and specifically expressed in glycolytic myofibers. Ablation of Tbx15 in vivo leads to a decrease in muscle size due t...

Manifold-driven Grouping of Skeletal Muscle Fibers

In this report, we present a manifold clustering method for the classification of fibers obtained from diffusion tensor images (DTI) of the human skeletal muscle. To this end, we propose the use of angular Hilbertian metrics between multivariate normal distributions to define a family of distances between tensors that we generalize to fibers. The obtained metrics between fiber tracts encompasse...

Muscle fibre type and obstructive sleep apnea.

Muscular pharyngeal structural changes, as fibre type disproportion, have been described in patients affected by Obstructive Sleep Apnea (OSA) and in an animal experimental OSA model. The unsolved question is whether these muscular abnormalities are either secondary to a compensatory increased activity or due to a constitutionally determined reduction of slow-alpha motor neurons. In the present...

Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type.

AMP deaminase (AMPD) is characterized by a multigene family in rodents and man. Highly conserved rat and human AMPD1 and AMPD2 genes produce protein products that exhibit cross-species immunoreactivities (AMPD1, rat isoform A and human isoform M; AMPD2, rat isoform B and human isoform L). A third gene, AMPD3, has been described in humans, but antisera raised against its purified protein product...